The significance of ApoB as a predictor compared to other biomarkers
Apolipoproteins, such as ApoB, are the protein components of all plaque forming lipoproteins. According to leading cardiovascular doctors and scientists, ApoB is a better predictor of heart disease risk than traditional cholesterol markers, as it accounts for all plaque forming atherogenic particles in the blood, including LDL-P and, VLDL, IDL, and Lip(A).

Since every plaque forming particle contains a ApoB molecule (1:1 ratio), we can further access the size and composition of these particles and this is key in assessing cardiovascular risk.
For example, studies have shown that more, smaller LDL particles are considered more dangerous compared to fewer, larger LDL-P particles as they can more easily generate plaque and accumulate your arteries. Both having more, smaller or less, larger particles would give the same LDL-P result, but more particles means a higher ApoB level. By testing your ApoB, it is possible to identify the presence of these smaller, denser, and more dangerous particles in your arteries, giving a more accurate result according to consensus among lipid experts.
The assessment of cardiovascular disease (CVD) can be limited by relying solely on total cholesterol levels, as it is possible to have a high number of small LDL-P particles while still testing within the normal cholesterol range. This presents a barrier and flaw in the current evaluation process for CVD. ApoB testing plays a crucial role in identifying this important distinction. Unlike an LDL-P test, an ApoB test can reveal whether the total cholesterol in your body is distributed among only 100 particles or 1000 particles. This information provides a more precise understanding of your cardiovascular health and can help in assessing the risk of CVD more accurately.